I suggest you do not actually want big knuckles. The enlargement of the knuckles may be osteoarthritis, a painful, degenerative condition where your hands will stiffen over time. Although it may serve as an external indicator that you have trained martial arts, once you have it, you would ask how to get rid of it. This is similar to grapplers trying to give themselves cauliflower ear; they want to look like their idols by intentionally damaging the body.
Once you do this kind of damage to your body, it may be irreversible. You can exercise your joints to retain range of motion and reduce pain, improve diet or take supplements (efficacy questioned), and see your doctor; but there are no guarantees your body can repair the damage. The WebMD link above outlines treatment options.
Intelligent training avoids unnecessary injuries.